Project information
Novel function of CDK12 in regulation of functional differentiation of mammary epithelial cells (Fundi12)

Lactation is a critical physiological process requiring precise coordination of cellular functions, including DNA replication, transcription, and the DNA damage response, to support milk production. This project aims to unravel the molecular mechanisms underlying these processes in lactating mammary epithelial cells. Using a cutting-edge lactation organoid model developed in our laboratory, combined with in vivo mouse models, the project will explore how DNA replication and transcription and DNA damage response regulate differentiation of luminal cells to milk-secreting binucleated alveolar cells. Advanced imaging techniques, transcriptomics, and molecular biology tools will be employed to investigate these pathways in detail. The findings will provide new insights into the fundamental biology of lactation and identify novel targets for addressing lactation-related disorders, contributing to improved maternal and neonatal health.