Go to main content | Go to main menu | Go to search

Project information
Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia: a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease progress

Information

This project doesn't include Faculty of Science. It includes Central European Institute of Technology. Official project website can be found on muni.cz.
Project Identification
NV19-03-00091
Project Period
5/2019 - 12/2022
Investor / Pogramme / Project type
Ministry of Health of the CR
  • Ministry of Health Research Programme 2015 - 2022
MU Faculty or unit
Central European Institute of Technology
Cooperating Organization
University Hospital Brno-Bohunice
  • Responsible person Mgr. Veronika Navrkalová, Ph.D.

Chronic lymphocytic leukemia (CLL) is common and still incurable leukemia of adults characterized by remarkable genetic and clinical heterogeneity. In proposed project we aim to study genetic background underlying clonal evolution of genomic alterations in treatment naïve CLL patients taking the advantage of availability of consecutive samples collected during disease course. Our main objective is to early disclose the disease progression and therapy need. We plan to assess both the prognostic and the predictive value of genomic aberrations detected just before treatment start. For this purpose, a highly complex next-generation sequencing (NGS) tool analyzing simultaneously both fundamental, as well as novel CLL biomarkers will be implemented. We employ benefits of capture-based NGS technology enabling to analyze in one test IGHV mutational status, recurrent chromosomal and gene defects, and Ig light chains clonality. We presume that our NGS panel tailored for CLL can be widely adopted in clinical practice as a simple comprehensive test for better patient prognostication.

Publications

Total number of publications: 52

2022

2021

  • A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

    JONES W. GONG B.S. NOVORADOVSKAYA N. LI D. KUSKO R. RICHMOND T.A. JOHANN D.J. BISGIN H. SAHRAEIAN S.M.E. BUSHEL P.R. PIROOZNIA M. WILKINS K. CHIERICI M. BAO W.J. BASEHORE L.S. LUCAS A.B. BURGESS D. BUTLER D.J. CAWLEY S. CHANG C.J. CHEN G.C. CHEN T. CHEN Y.C. CRAIG D.J. DEL POZO A. FOOX J. FRANCESCATTO M. FU YT FURLANELLO C. GIORDA K. GRIST K.P. GUAN M.J. HAO Y.Y. HAPPE S. HARIANI G. HASELEY N. JASPER J. JURMAN G. KREIL D.P. LABAJ P. LAI K. LI J.Y. LI Q.Z. LI Y.L. LI Z.G. LIU Z.C. LOPEZ M.S. MICLAUS K. MILLER R. MITTAL V.K. MOHIYUDDIN M. PABON-PENA C. PARSONS B.L. QIU F.J. SCHERER A. SHI T.L. STIEGELMEYER S. SUO C. TOM Nikola WANG D. WEN Z.N. WU L.H. XIAO W.Z. XU C. YU Y. ZHANG J.Y. ZHANG Y.F. ZHANG Z.H. ZHENG Y.T. MASON C.E. WILLEY J.C. TONG W.D. SHI L.M. XU J.

    Article in Periodical

    GENOME BIOLOGY, year: 2021, volume: 22, edition: 1, DOI

  • Bioinformatic strategies for the analysis of genomic aberrations detected by targeted NGS panels with clinical application

    HYNŠT Jakub NAVRKALOVÁ Veronika PÁL Karol POSPÍŠILOVÁ Šárka

    Article in Periodical

    PeerJ, year: 2021, volume: 9, edition: MAR 2021, DOI

  • Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study

    SUTTON L.A. LJUNGSTROM V. ENJUANES A. CORTESE D. SKAFTASON A. TAUSCH E. STAŇO KOZUBÍK Kateřina NADEU F. ARMAND M. MALČÍKOVÁ Jitka PANDZIC T. FORSTER J. DAVIS Z. OSCIER D. ROSSI D. GHIA P. STREFFORD J.C. POSPÍŠILOVÁ Šárka STILGENBAUER S. DAVI F. CAMPO E. STAMATOPOULOS K. ROSENQUIST R.

    Article in Periodical

    haematologica, year: 2021, volume: 106, edition: 3, DOI

  • Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

    GONG B.S. LI D. KUSKO R. NOVORADOVSKAYA N. ZHANG Y.F. WANG S.Z. PABON-PENA C. ZHANG Z.H. LAI K. CAI W.S. LOCOCO J.S. LADER E. RICHMOND T.A. MITTAL V.K. LIU L.C. JOHANN D.J. WILLEY J.C. BUSHEL P.R. YU Y. XU C. CHEN G.C. BURGESS D. CAWLEY S. GIORDA K. HASELEY N. QIU F.J. WILKINS K. ARIB H. ATTWOOLL C. BABSON K. BAO L.L. BAO W.J. LUCAS A.B. BEST H. BHANDARI A. BISGIN H. BLACKBURN J. BLOMQUIST T.M. BOARDMAN L. BURGHER B. BUTLER D.J. CHANG C.J. CHAUBEY A. CHEN T. CHIERICI M. CHIN C.R. CLOSE D. CONROY J. COLEMAN J.C. CRAIG D.J. CRAWFORD E. DEL POZO A. DEVESON I.W. DUNCAN D. ETEROVIC A.K. FAN X.H. FOOX J. FURLANELLO C. GHOSAL A. GLENN S. GUAN M.J. HAAG C. HANG X.Y. HAPPE S. HENNIGAN B. HIPP J. HONG H.X. HORVATH K. HU J.H. HUNG L.Y. JAROSZ M. KERKHOF J. KIPP B. KREIL D.P. LAPUNZINA P. LI P. LI Q.Z. LI W.H. LI Z.G. LIANG Y. LIU S.Q. LIU Z.C. MA C. MARELLA N. MARTIN-ARENAS R. MEGHERBI D.B. MENG Q.C. MIECZKOWSKI P.A. MORRISON T. MUZNY D. NING B.T. PARSONS B.L. PAWELETZ C.P. PIROOZNIA M. QU W.B. RAYMOND A. RINDLER P. RINGLER R. SADIKOVIC B. SCHERER A. SCHULZE E. SEBRA R. SHAKNOVICH R. SHI Q. SHI T.L. SILLA-CASTRO J.C. SMITH M. LOPEZ M.S. SONG P. STETSON D. STRAHL M. STUART A. SUPPLEE J. SZANKASI P. TAN H.W. TANG L.Y. TAO Y.H. THAKKAR S. THIERRY-MIEG D. THIERRY-MIEG J. THODIMA V.J. THOMAS D. TICHÝ Boris TOM Nikola GARCIA E.V. VERMA S. WALKER K. WANG C. WANG J.W. WANG Y.X. WEN Z.N. WIRTA V. WU L.H. XIAO C.L. XIAO W.Z. XU S.B. YANG M. YING J.M. YIP S.H. ZHANG G.L. ZHANG S. ZHAO M.R. ZHENG Y.T. ZHOU X.Y. MASON C.E. MERCER T. TONG W.D. SHI L.M. JONES W. XU J.S.

    Article in Periodical

    GENOME BIOLOGY, year: 2021, volume: 22, edition: 1, DOI

  • Dynamika mutací a chromozomálních aberací v závislosti na aktivitě CLL u neléčených pacientů.

    NAVRKALOVÁ Veronika KOTAŠKOVÁ Jana VALIŠOVÁ Martina ŽENATOVÁ Marcela PANOVSKÁ Anna DOUBEK Michael POSPÍŠILOVÁ Šárka

    Conference abstract

    Year: 2021, type: Conference abstract

  • Dynamika mutací a chromozomálních aberací v závislosti na aktivitě CLL u neléčených pacientů.

    NAVRKALOVÁ Veronika KOTAŠKOVÁ Jana VALIŠOVÁ Martina ŽENATOVÁ Marcela PANOVSKÁ Anna DOUBEK Michael POSPÍŠILOVÁ Šárka

    Conference abstract

    Year: 2021, type: Conference abstract

Previous 1 2 3 4 5 6 Next

You are running an old browser version. We recommend updating your browser to its latest version.