Loschmidt Laboratories of Protein Engineering

Articles

• Acridine-Based Chalcone 1C and ABC Transporters

  FRANKO Ondrej CIZMARIKOVA Martina KELLO Martin MICHALKOVA Radka WESOLOWSKA Olga SRODA-POMIANEK Kamila MARQUES Sérgio Manuel BEDNÁŘ David HAZIKOVA Viktoria LISKA Tomas Jan HABALOVA Viera

  Article in Periodical

  International Journal of Molecular Sciences, year: 2025, volume: 26, edition: 9, DOI

• Anticipating protein evolution with successor sequence predictor

  KHAN Rayyan Tariq KOHOUT Pavel MUSIL Miloš ROSINSKA Monika DAMBORSKÝ Jiří MAZURENKO Stanislav BEDNÁŘ David

  Article in Periodical

  Journal of Cheminformatics, year: 2025, volume: 17, edition: 1, DOI

• Automated Engineering Protein Dynamics via Loop Grafting: Improving Renilla Luciferase Catalysis

  PLANAS IGLESIAS Joan MAJEROVÁ Marika PLUSKAL Daniel VAŠINA Michal DAMBORSKÝ Jiří PROKOP Zbyněk MAREK Martin BEDNÁŘ David

  Article in Periodical

  ACS Catalysis, year: 2025, volume: 15, edition: 4, DOI

• Biochemical and Computational Characterization of Haloalkane Dehalogenase Variants Designed by Generative AI: Accelerating the SN2 Step

  GELFAND Natalia OREL Vojtěch CUI Wenqiang DAMBORSKÝ Jiří LI Chenglong PROKOP Zbyněk XIE Wen Jun WARSHEL Arieh

  Article in Periodical

  Journal of the American Chemical Society, year: 2025, volume: 147, edition: 3, DOI

• Caver Web 2.0: analysis of tunnels and ligand transport in dynamic ensembles of proteins

  MARQUES Sérgio Manuel BORKO Simeon VÁVRA Ondřej DVORSKÝ Jan KOHOUT Petr KABOUREK Petr HEJTMÁNEK Lukáš DAMBORSKÝ Jiří BEDNÁŘ David

  Article in Periodical

  Nucleic acids research, year: 2025, volume: 53, edition: May 2025, DOI

• Discovery of new inhibitors of nuclease MRE11

  NIKULENKOV Fedor CARBAIN Benoit Jean-Pierre BISWAS Raktim HAVEL Štěpán PROCHÁZKOVÁ Jana SISÁKOVÁ Alexandra ZACPALOVÁ Magdaléna CHAVDAROVA Melita MARINI PALOMEQUE María Victoria VŠIANSKÝ Vít WEISOVÁ Veronika SLÁVIKOVÁ Kristína BIRADAR Dhanraj Omprakash KHIRSARIYA PrashantKumar VITEK Marco SEDLAK David BARTUNEK Petr DANIEL Lukáš BREZOVSKÝ Jan DAMBORSKÝ Jiří PARUCH Kamil KREJČÍ Lumír

  Article in Periodical

  European Journal of Medicinal Chemistry, year: 2025, volume: 285, edition: March, DOI

• Engineering Dehalogenase Enzymes Using Variational Autoencoder-Generated Latent Spaces and Microfluidics

  KOHOUT Pavel VAŠINA Michal MAJEROVÁ Marika NOVÁKOVÁ Veronika DAMBORSKÝ Jiří BEDNÁŘ David MAREK Martin PROKOP Zbyněk MAZURENKO Stanislav

  Article in Periodical

  JACS AU, year: 2025, volume: 5, edition: 2, DOI

• Functional Characterization of Luciferase in a Brittle Star Indicates Parallel Evolution Influenced by Genomic Availability of Haloalkane Dehalogenase

  LAU Emily S. MAJEROVÁ Marika HENSLEY Nicholai M. MUKHERJEE Arnab VAŠINA Michal PLUSKAL Daniel DAMBORSKÝ Jiří PROKOP Zbyněk DELROISSE Jerome BAYAERT Wendy-Shirley PAREY Elise OLIVERI Paola MARLETAZ Ferdinand MAREK Martin OAKLEY Todd H.

  Article in Periodical

  Molecular Biology and Evolution, year: 2025, volume: 42, edition: 5, DOI

• Global analysis by LC-MS/MS of N6-methyladenosine and inosine in mRNA reveal complex incidence

  STEJSKAL Stanislav ŠEMBEROVÁ RÁJECKÁ Veronika COVELO MOLARES Helena SINIGAGLIA Ketty BROŽINOVÁ Květoslava KAŠIAROVÁ Linda DOHNÁLKOVÁ Michaela REYES-GUTIERREZ Paul Eduardo CAHOVÁ Hana KEEGAN Liam O'CONNELL Mary Anne VAŇÁČOVÁ Štěpánka

  Article in Periodical

  RNA, year: 2025, volume: 31, edition: 4, DOI

• Glycated α-Synuclein Renders Glial Cell Activation and Induces Degeneration of Dopaminergic Neurons: A Potential Implication for the Development of Parkinson's Disease

  CHATTERJEE Sayan VERMA Arvind THAKKAR Harsh SHAH Ravi P KHAIRNAR Amit Suresh

  Article in Periodical

  ACS Chemical Biology, year: 2025, DOI