Mgr. Jiří Holoubek, Ph.D.

2025

• Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain.

  BERÁNKOVÁ Michaela HOLOUBEK Jiří HÖNIG Václav MATUSOVA Zuzana PALUS Martin SALÁT Jiří KRAYEM Imtissal VOJTISKOVA Jarmila SVOBODA Pavel PRANCLOVA Veronika VALIHRACH Lukas DEMANT Peter LIPOLDOVA Marie RŮŽEK Daniel

  Article in Periodical

  Journal of Neuroinflammation, year: 2025, volume: 22, edition: 1, DOI

• Influence of the pre-membrane and envelope proteins on structure, pathogenicity, and tropism of tick-borne encephalitis virus.

  ROSENDAL Ebba BISIKALO Kyrylo WILLEKENS Stefanie MA LINDGREN Marie HOLOUBEK Jiří SVOBODA Pavel LAPPALAINEN Amanda KÖNIGHOFER Ebba MIRGORODSKAYA Ekaterina NORDÉN Rickard MORINI Federico ROSENBAUM William RŮŽEK Daniel AHLGREN Ulf ANASTASINA Maria MERITS Andres BUTCHER Sarah J NILSSON Emma ÖVERBY Anna K

  Article in Periodical

  Journal of Virology, year: 2025, edition: e0087025, DOI

• Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious

  HOLOUBEK Jiří SALÁT Jiří MATKOVIC Milos BEDNÁŘ Petr NOVOTNÝ Pavel HRADILEK Martin MAJEROVÁ Taťána ROSENDAL Ebba EYER Luděk FOŘTOVÁ Andrea BERÁNKOVÁ Michaela BELL-SAKYI Lesley ÖVERBY Anna K CAVALLI Andrea BONOMI Massimiliano REY Felix A RŮŽEK Daniel

  Article in Periodical

  Nature Communications, year: 2025, volume: 16, edition: 1, DOI

• Membrane-Active Singlet Oxygen Photogenerators as a Paradigm for Broad-Spectrum Antivirals: The Case of Halogenated (BOron)-DIPYrromethenes

  MARYEWSKI Xenia A. KRASILNIKOV Maxim S. STRAKOVÁ Petra HOLOUBEK Jiří FRČKOVÁ Tereza PANINA Irina S. KRYLOV Nikolay A. GVOZDEV Daniil A. DENISOV Vladislav S. SEMENOV Alexey N. LOTOSH Natalia Y. SELISHCHEVA Alla A. CHISTOV Alexey A. GULYAK Evgeny L. KOZHEMYAKIN Grigory L. KORSHUN Vladimir A. EFREMOV Roman G. USTINOV Alexey V. RŮŽEK Daniel EYER Luděk ALFEROVA Vera A.

  Article in Periodical

  ACS Applied Materials and Interfaces, year: 2025, volume: 17, edition: 3, DOI

• Three-dimensional mapping of tick-borne encephalitis virus distribution in the mouse brain using a newly engineered TurboGFP reporter virus

  BERÁNKOVÁ Michaela LEONI Simone HOLOUBEK Jiří HAVIERNIK Jan SALÁT Jiří GRANDGIRARD Denis LEIB Stephen L RŮŽEK Daniel

  Article in Periodical

  Emerging Microbes and Infections, year: 2025, volume: 14, edition: 1, DOI

2024

• Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: Blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope

  HOLOUBEK Jiří SALÁT Jiří KOTOUČEK Jan KASTL Tomáš VANCOVÁ Marie HUVAROVÁ Ivana BEDNÁŘ Petr BEDNÁŘOVÁ Klára RŮŽEK Daniel RENČIUK Daniel EYER Luděk

  Article in Periodical

  Antiviral Research, year: 2024, volume: 221, edition: January 2024, DOI

• Exploring the transcriptomic profile of human monkeypox virus via CAGE and native RNA sequencing approaches

  NAGY Gergely armin TOMBACZ Dora PRAZSAK Istvan CSABAI Zsolt DORMO Akos GULYAS Gabor KEMENESI Gabor TOTH Gabor E HOLOUBEK Jiří RŮŽEK Daniel KAKUK Balazs BOLDOGKOI Zsolt

  Article in Periodical

  mSphere, year: 2024, volume: 9, edition: 9, DOI

2023

• Alkyl Derivatives of Perylene Photosensitizing Antivirals: Towards Understanding the Influence of Lipophilicity

  MIKHNOVETS Igor E. HOLOUBEK Jiří PANINA Irina S. KOTOUČEK Jan GVOZDEV Daniil A. CHUMAKOV Stepan P. KRASILNIKOV Maxim S. ZHITLOV Mikhail Y. GULYAK Evgeny L. CHISTOV Alexey A. NIKITIN Timofei D. KORSHUN Vladimir A. EFREMOV Roman G. ALFEROVA Vera A. RŮŽEK Daniel EYER Luděk USTINOV Alexey V.

  Article in Periodical

  International Journal of Molecular Sciences, year: 2023, volume: 24, edition: 22, DOI

• Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion inactivation

  STRAKOVÁ Petra BEDNÁŘ Petr KOTOUČEK Jan HOLOUBEK Jiří FOŘTOVÁ Andrea SVOBODA Pavel ŠTEFÁNIK Michal HUVAROVÁ Ivana ŠIMEČKOVÁ Pavlína MAŠEK Josef GVOZDEV Daniil A MIKHNOVETS Igor E CHISTOV Alexey A NIKITIN Timofei D KRASILNIKOV Maxim S USTINOV Alexey V ALFEROVA Vera A KORSHUN Vladimir A RŮŽEK Daniel EYER Luděk

  Article in Periodical

  Virus Research, year: 2023, volume: 334, edition: September, DOI

• In-depth Temporal Transcriptome Profiling of Monkeypox and Host Cells using Nanopore Sequencing

  KAKUK Balázs DÖRMŐ Ákos CSABAI Zsolt KEMENESI Gábor HOLOUBEK Jiří RŮŽEK Daniel PRAZSÁK István DANI Virág Éva DÉNES Béla TORMA Gábor JAKAB Ferenc TÓTH Gábor E. FÖLDES Fanni V. ZANA Brigitta LANSZKI Zsófia HARANGOZÓ Ákos FÜLÖP Ádám GULYÁS Gábor MIZIK Máté KISS András Attila TOMBÁCZ Dóra BOLDOGKŐI Zsolt

  Article in Periodical

  Scientific Data, year: 2023, volume: 10, edition: 262, DOI